|The IUCr is an International Scientific Union. Its objectives are to promote international cooperation in crystallography and to contribute to all aspects of crystallography, to promote international publication of crystallographic research, to facilitate standardization of methods, units, nomenclatures and symbols, and to form a focus for the relations of crystallography to other sciences.|
The International Union of Crystallography (IUCr) is seeking an Executive Secretary to manage the organization, and to administer its day-to-day operations.
The IUCr is a Scientific Union and publisher. It is governed by a General Assembly that meets every three years; between these meetings the work of the Union is delegated to the Executive Committee. The Executive Secretary reports to the Executive Committee through the General Secretary.
The IUCr has offices in Chester, UK, and employs 25 staff, chiefly in its publishing operations. The successful candidate is expected to direct the financial and administrative affairs of the Union, which has 50 Adhering Bodies and 23 Commissions, as well as having responsibility for the staff.
The successful applicant will have a degree or PhD, ideally with experience within an international or not-for-profit organization, and a good knowledge of English. The ability to handle financial matters such as overseeing the preparation of the annual accounts by external accountants and dealing with taxation and investment matters is required.
To apply for the position, send a CV, names of two referees, and a covering letter to Mike Dacombe (email@example.com) by 15 February 2017.
There are eight papers on various aspects of radiation damage in the latest issue of the Journal of Synchrotron Radiation. The studies reported on macromolecular crystallography (MX) and small-angle scattering (SAXS) experiments were presented at the 9th International Workshop on Radiation Damage to Biological Crystalline Samples, held at MAX IV in Lund in March 2016 [Garman & Weik (2017), J. Synchrotron. Rad. 24, 1-6; doi: 10.1107/S160057751602018X].
There have been concerted efforts over the last 15 years to understand the manifestations and origins of radiation damage suffered by protein crystals during MX experiments, and to establish mitigation strategies using various approaches. These have gradually resulted in a deeper understanding of the physical, chemical and structural factors affecting damage rates, and there is a growing literature which seeks to elucidate the pertinent parameters. As the range and scope of the investigations have broadened, so has our appreciation of the complexities of radiation damage phenomena, although a full knowledge of all processes involved has not yet been achieved. The need for this has, however, become more pressing, especially with the advent of X-ray free-electron lasers and new fourth-generation synchrotron sources such as MAX IV in Lund and NSLS II at Brookhaven now coming on-line with even higher flux densities than hitherto utilised. The high rate of damage inflicted by these X-ray beams has brought the issue of radiation damage during structural biology experiments into even sharper focus. Thus, an awareness of the effects of radiation damage both on diffraction and SAXS data, and on the macromolecular structures derived from them, will become increasingly important.The papers in the special issue include: a re-examination of structural damage to tyrosine residues; two papers on finding the optimum MX data collection strategy for phasing of structures, one using sulfur SAD data in the presence of damage and the other on anomalous phasing with mercury by serial synchrotron data collection; a comparison of helical and standard rotation methods from a radiation damage standpoint; two papers examining damage rates in SAXS experiments and scavengers that could be used to reduce these rates as well as presenting some new visualisation tools; an analysis of the conformational heterogeneity of side chains as a function of dose in room-temperature and cryo-crystallography, and, finally, an imaging study on the effects of X-ray irradiation on microcrystals.
A beam circulated for the first time in the pioneering SESAME synchrotron at 18:12(UTC+3) on 11 January 2017. The next step will be to store the beam.
This is an important milestone on the way to research getting underway at the first light-source laboratory in the Middle East. SESAME was established under the auspices of UNESCO before becoming a fully independent intergovernmental organisation in its own right in 2004. SESAME’s Members are Bahrain, Cyprus, Egypt, Iran, Israel, Jordan, Pakistan, the Palestinian Authority and Turkey. Its mission is to provide a world-class research facility for the region, while fostering international scientific cooperation. The first call for proposals to carry out research at SESAME was recently issued.
Talking to reporters, Professor Khaled Toukan, SESAME Director said, “SESAME is now opening for business.”
SESAME, which stands for Synchrotron-light for Experimental Science and Applications in the Middle East, is a light-source; a particle accelerator-based facility that uses electromagnetic radiation emitted by circulating electron beams to study a range of properties of matter. Experiments at SESAME will enable research in fields ranging from medicine and biology, through materials science, physics and chemistry to healthcare, the environment, agriculture and archaeology.
“This is a great day for SESAME”, said Professor Sir Chris Llewellyn-Smith, President of the SESAME Council. “It’s a tribute to the skill and devotion of the scientists and decision-makers from the region who have worked tirelessly to make scientific collaboration between countries in the Middle East and neighbouring regions a reality.”
The first circulating beam is an important step on the way to first light, which marks the start of the research programme at any new synchrotron light-source facility, but there is much to be done before the experiments can get underway. Beams have to be accelerated to SESAME’s operating energy of 2.5 GeV. Then the light emitted as the beams circulate has to be channelled along SESAME’s two day-one beamlines and optimised for the experiments that will take place there. This process is likely to take around six months, leading to first experiments in the summer of 2017.This is a short excerpt taken from a press release published by SESAME
Acta Crystallographica Section C: Structural Chemistry is pleased to announce the appointment of two new Section Editors, Professors Larry Falvello and Jonathan White.
Since 1991, Falvello has been Professor of Inorganic Chemistry at the University of Zaragoza, where he is also a member of the Aragón Materials Science Institute. Falvello's research programme in the physical properties and transformations of molecular solids combines the synthesis of new coordination compounds of transition metals and lanthanoids, using ligands rich in functional groups, with their structural characterization and studies of their physical properties and possible transformations.
Falvello has been Co-Editor at Acta Crystallographica Section C since 2002 and served as Deputy Section Editor in 2013-2014. He was Associate Editor of Comments on Inorganic Chemistry from 2002 to 2014. Having been trained near the end of the "old times" of crystallography and having lived the advances of the past four decades, he sees Acta Crystallographica Section C: Structural Chemistry as being uniquely positioned to maintain rigorous standards in the publication and conservation of structural results, while at the same time providing its readers with the extended chemical context that motivated a particular study and, more importantly, with the advances in chemical understanding that resulted from that study.
White was appointed to the University of Melbourne School of Chemistry in 1991, and has been Professor of Chemistry there since 2014.
White’s wide research programme includes structural organic chemistry, where he has applied the Structure Correlation Principle to a number of organic chemical reactions and rearrangements. He is also particularly interested in the use of accurate low-temperature X-ray determinations of model organic compounds to investigate donor-acceptor interactions between a variety of functional groups in both organic and organometallic compounds.
White has been Co-Editor at Acta Crystallographica Section C since 2011. He has been the Associate Editor for crystallography for the Australian Journal of Chemistry from 2010 and is a consultant crystallographer to the ACS journal Organic Letters.
Both see Acta Crystallographica Section C as a journal of chemical crystallography where significant structures are presented in the context of the underlying chemistry. They see the journal being of interest to a wide audience from materials scientists and structural chemists to researchers using amongst other techniques, magnetic resonance, electronic spectroscopy, and those involved in computational modelling and the knowledge-based exploration of chemical structures.You can see a list of IUCr papers published by Professor J.M. White here, and IUCr papers published by Professor Larry Falvello here.
The IUCr would like to congratulate the structural biologist Nenad Ban, who is to be awarded the Ernst Jung Prize for Medicine 2017 for his description of the atomic structure of cellular protein production machinery.
In a press release from the Jung Foundation Ban says, “I am delighted and honoured to be receiving the Ernst Jung Prize, on behalf of not only myself but my whole team. This award is also an acknowledgement of the interdisciplinary approach in structural biology that we have built up over many years at ETH in order to study cellular function”. In addition he says, it highlights the importance of fundamental research for understanding medically relevant cellular processes.
The Ernst Jung Prize for Medicine is the Jung Foundation for Science and Research’s medical award which was first awarded in 1976. The prize is currently valued at 300,000 Euros.
Laureates of the Ernst Jung Prize for Medicine rank amongst some of the top representatives in their field.This is a short extract taken from a press release issued by ETH Zurich
The 16th International Conference on Small-Angle Scattering (SAS2015) was held in Berlin, Germany, in 2015. A fully open-access virtual special edition of Journal of Applied Crystallography publishes work that provides insights into ongoing developments in the field of small-angle neutron and X-ray scattering (SANS and SAXS) covering different areas of fundamental and applied research. Some of the highlights from the issue include a paper from Lehmkühler et al. (2016) which describes the use of X-ray cross correlation analysis applied to the investigation of colloidal crystals. For the case of poly(methyl methacrylate) colloids it is shown how information beyond the static structure factor can be deduced from coherent X-ray scattering experiments, for example, enabling assignment of a face-centred cubic structure to the crystal. In a different direction the work by Perkins et al. (2016) dwells on the current state of the atomistic modelling of scattering data and reviews the achievement of the Collaborative Computational Project for Small Angle Scattering (CCP-SAS). Certainly these developments will be important for the future when increasingly complex systems will probably need to be characterised by SAS with atomistic resolution.
SAS has become increasingly important over the years for the investigation of soft matter systems. An interesting example of such an investigation is given by Prevost et al. (2016), which successfully shows how to obtain detailed structural information on so-called “ultra-flexible microemulsions”. This is a novel type of self-assembled system that exhibits microemulsion structures even in the absence of a typical surfactant, as was elucidated here using a combination of SAXS and wide-angle X-ray scattering.
Synthetic systems can also be of high scientific interest as demonstrated in a paper by Kaneko et al. (2016) in the case of syndiotactic polystyrene cocrystals with polyethylene glycol dimethyl ether. The temperature-dependent changes from crystalline to more amorphous structures were obtained by combining SANS investigations with simultaneous Fourier transform infrared spectroscopy measurements.
Another way of coupling SAS experiments with complementary information is shown by Jordan et al. (2016), who demonstrate how size exclusion chromatography (SEC) can be coupled to SANS experiments. Instrumentation is also the focus of Li et al. (2016), who report on the state of the BioSAXS beamline BL19U2 at the National Centre for Protein Sciences Shanghai. This new synchrotron SAXS beamline is dedicated to meeting the increasing demands of researchers from the field of structural biology.
The topics contained in the special issue describe the particular directions in which SAS is developing at the moment and which will become increasingly important in the future. There will no doubt be further substantial advances of the SAS technique, itself, and its application to solve important scientific questions in diverse research areas.This is a short extract taken from an editorial published in J. Appl. Cryst. (2016), 49, 1858-1860